Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment
Jacinta Jacob, Suchita Nadkarni, Alessia Volpe, Qi Peng, Sim L. Tung, Rosalind Hannen, Yasmin R. Mohseni, Cristiano Scottà, Federica M. Marelli‐Berg, Robert I. Lechler, Lesley A. Smyth, Gilbert O. Fruhwirth, Giovanna Lombardi
Abstract
tracking, addressing a fundamental need in Treg therapy development and offering a clinically compatible methodology for future Treg therapy imaging in humans.
Topics & Concepts
ImmunologyInnate immune systemImmune systemIn vivoTreg cellPolyclonal antibodiesBiologyCell biologyInnate lymphoid cellT cellGeneticsAntibodyIL-2 receptorCAR-T cell therapy researchT-cell and B-cell ImmunologyImmune Cell Function and Interaction