The complex role of prostaglandin E<sub>2</sub>-EP receptor signaling in wound healing
Kristy E. Gilman, Kirsten H. Limesand
2020American Journal of Physiology-Regulatory, Integrative and Comparative Physiology34 citationsDOIOpen Access PDF
Abstract
Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E 2 (PGE 2 ) being the most complex and exhibiting the most diverse physiological outputs. PGE 2 signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE 2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.
Topics & Concepts
Wound healingReceptorProstaglandin E2 receptorSignal transductionCell biologyLipid signalingProstaglandin E2ProstaglandinChemistryBiologyBiochemistryEndocrinologyImmunologyAgonistInflammatory mediators and NSAID effectsNF-κB Signaling PathwaysSesquiterpenes and Asteraceae Studies