Multi-Level Regulation of Opioid-Induced Respiratory Depression
Barbara Palković, Vitaliy Marchenko, Edward J. Zuperku, Eckehard A. E. Stuth, Astrid G. Stucke
Abstract
Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBötzinger Complex as well as from depression of the Parabrachial/Kölliker-Fuse Complex, which provides excitatory drive to preBötzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.
Topics & Concepts
ForebrainRespiratory systemExcitatory postsynaptic potentialOpioidVentilation (architecture)Depression (economics)NeuroscienceRespiratory rateParabrachial NucleusAnesthesiaLateral parabrachial nucleusRespiratory centerControl of respirationMedicinePharmacologyBiologyInternal medicineHeart rateReceptorCentral nervous systemInhibitory postsynaptic potentialPhysicsMacroeconomicsBlood pressureEconomicsThermodynamicsNeuroscience of respiration and sleepNeuroendocrine regulation and behaviorCircadian rhythm and melatonin