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A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)

Hong Xu, Laurence H. Hurley

2022Bioorganic & Medicinal Chemistry Letters80 citationsDOI

Topics & Concepts

NucleolinChemistryRNAG-quadruplexNucleolusDNACancer researchComputational biologyGeneticsMolecular biologyBiologyBiochemistryGeneCytoplasmDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesCancer therapeutics and mechanisms
A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex) | Litcius