Role of vitamin B12 and folic acid in treatment of Alzheimer’s disease: a meta-analysis of randomized control trials
Chih-Ying Lee, Lung Chan, Chaur-Jong Hu, Chien‐Tai Hong, Jia‐Hung Chen
Abstract
= 0.68) or measures of daily life function. Blood homocysteine levels were significantly decreased after vitamin B12 and folic acid treatment. Participants with AD who received 6 months of vitamin B12 and folic acid supplementation had better MMSE scores but had no difference in ADAS-Cog scores. Daily life function did not improve after treatment.
Topics & Concepts
Vitamin B12Folic acidRandomized controlled trialMedicineMeta-analysisAlzheimer's diseaseDiseaseInternal medicineFolate and B Vitamins ResearchPharmacological Effects and Toxicity StudiesAlcoholism and Thiamine Deficiency