KPC-53, a KPC-3 Variant of Clinical Origin Associated with Reduced Susceptibility to Ceftazidime-Avibactam
Vincenzo Di Pilato, Noemi Aiezza, Valentina Viaggi, Alberto Antonelli, Luigi Principe, Tommaso Giani, Francesco Luzzaro, Gian María Rossolini
Abstract
This study reports on the characterization of a Klebsiella pneumoniae clinical isolate showing high-level resistance to ceftazidime-avibactam associated with the production of KPC-53, a KPC-3 variant exhibiting a Leu167Glu168 duplication in the Ω-loop and a loss of carbapenemase activity. Whole-genome sequencing (WGS) revealed the presence of two copies of bla KPC-53 , located on a pKpQIL-like plasmid and on a plasmid prophage of the Siphoviridae family, respectively.
Topics & Concepts
Ceftazidime/avibactamKlebsiella pneumoniaeProphagePlasmidCeftazidimeBiologyAvibactamGene duplicationGenotypingGeneticsMicrobiologyGenotypeDNAGeneBacteriophageBacteriaPseudomonas aeruginosaEscherichia coliAntibiotic Resistance in BacteriaGenomics and Phylogenetic StudiesPlant Pathogenic Bacteria Studies