Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment
Pedram Moeini, Paulina Niedźwiedzka‐Rystwej
Abstract
Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited into the tumor microenvironment. Their role in cancer progression, metastasis, and therapy failure is of special note. The aim of this review is to understand how the presence of TAMs are both advantageous and disadvantageous in the immune system.
Topics & Concepts
Immune systemTumor microenvironmentInnate immune systemMacrophageCancer researchCancerMetastasisCancer treatmentCancer cellMedicineImmunologyCancer therapyTumor-associated macrophageBiologyInternal medicineIn vitroBiochemistryImmune cells in cancerPhagocytosis and Immune RegulationNanoplatforms for cancer theranostics