Nickel-Catalyzed Direct Cross-Coupling of Aryl Fluorosulfates with Aryl Bromides
Jin-He Na, Xiang Liu, Jia-Wen Jing, Jing Wang, Xue‐Qiang Chu, Mengtao Ma, Hao Xu, Xiaocong Zhou, Zhi‐Liang Shen
Abstract
A one-pot, direct cross-coupling of aryl fluorosulfate with aryl bromide, which is step-economical and avoids the use of a preprepared/commercial organometallic reagent, could be accomplished by performing the reaction in THF at room temperature in the presence of nickel catalyst, magnesium turnings, and lithium chloride, giving rise to the corresponding biaryls in moderate to good yields with reasonable functional group compatibility.
Topics & Concepts
ArylChemistryReagentNickelCatalysisMagnesiumBromideLithium bromideCoupling reactionChlorideCombinatorial chemistryOrganic chemistryPhysicsThermodynamicsHeat exchangerAlkylCatalytic Cross-Coupling ReactionsFluorine in Organic ChemistrySulfur-Based Synthesis Techniques