Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
Shih Chieh Chang, Pooja Gopal, Shuhui Lim, Xiaona Wei, Arun Chandramohan, Ruban Mangadu, Jeffrey S. Smith, Simon Ng, Marian E. Gindy, Uyen Phan, Brian Henry, Anthony W. Partridge
Topics & Concepts
Proliferating cell nuclear antigenApoptosisIn vivoUbiquitinBiologyUbiquitin ligaseProgrammed cell deathDNA damageMolecular biologyCancer researchMitosisCellCell biologyCell growthDNABiochemistryGeneticsGeneProtein Degradation and InhibitorsRNA Interference and Gene DeliveryPeptidase Inhibition and Analysis