<i>meso</i>-Tetra-(4-pyridyl)porphyrin/palladium(<scp>ii</scp>) complexes as anticancer agents
Kamilla M. Alves, João Honorato, Luciano M. Lião, Vivianne S. Velozo-Sá, Adriana P. M. Guedes, Jocely L. Dutra, Alejando P. Ayalla, Javier Ellena, Alzir A. Batista, Pablo José Gonçalves
Abstract
space group. The cytotoxicity of the complexes against MDA-MB-231 (breast cancer cells) and MCF-10A (non-tumor breast cancer cells), was determined by the colorimetric MTT method, which revealed that all four complexes show selective indexes close to 1.2, lower than that of cisplatin for the same cells (12.12). The interaction of the complexes with CT-DNA was evaluated by UV-visible and viscosity measurements and it was determined that the complexes interact moderately with CT-DNA, probably by H-bonding/π-π stacking and electrostatic interactions.
Topics & Concepts
ChemistryPalladiumPorphyrinButaneStackingCrystallographyFerroceneStereochemistryMedicinal chemistryPhotochemistryPhysical chemistryOrganic chemistryCatalysisElectrochemistryElectrodePorphyrin and Phthalocyanine ChemistryMetal complexes synthesis and propertiesSynthesis and Biological Evaluation