Identification of Carbazole Alkaloid Derivatives with Acylhydrazone as Novel Anti-TMV Agents with the Guidance of a Digital Fluorescence Visual Screening
Xianpeng Zhang, Wenbo Huang, Lu Xu, Sisi Liu, Hui Feng, Wanneng Yang, Junli Ye, Feng Li, Shaoyong Ke, Dengguo Wei
Abstract
(63%) exhibited anti-TMV activities comparable to that of ningnanmycin (65%) at 50 μM, and they delayed the multiplication of TMV in the early stage of infection without phytotoxicity. Taken together, these findings demonstrated that the digital and visual TMV-GFP screening method was competent to test the antiviral activities of compounds with subtle modifications and facilitated the discovery of novel antivirals.
Topics & Concepts
Tobacco mosaic virusCarbazoleFluorescenceComputational biologyChemistryVirologyViral replicationGreen fluorescent proteinCombinatorial chemistryBiologyChromatographyVirusBiochemistryPhotochemistryQuantum mechanicsPhysicsGenePlant Virus Research StudiesPlant Disease Resistance and GeneticsPlant-Microbe Interactions and Immunity