Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair
Diane Bruyère, Patrick Roncarati, Alizée Lebeau, Thomas Lerho, Florian Poulain, Elodie Hendrick, Charlotte Pilard, Célia Reynders, Marie Ancion, Margaux Luyckx, Michael Renard, Yves Jacob, Jean‐Claude Twizere, Raphaël Peiffer, Olivier Peulen, Philippe Delvenne, Pascale Hubert, Alison A. McBride, Nicolas Gillet, Murielle Masson, Michaël Herfs
Abstract
Taken together, our findings provide a molecular insight into the direct hijacking of host DNA damage/repair responses by HPV oncoproteins, demonstrate the significant impact of this phenomenon on both intrinsic cellular radiosensitivity and host DNA integrity and suggest novel connected therapeutic vulnerabilities.
Topics & Concepts
DNA damageBiologyDNA repairCancer researchGenome instabilityHomologous recombinationRadiation sensitivitySubcellular localizationDNA replicationCell biologyDNAMolecular biologyGeneticsNuclear physicsIrradiationPhysicsCytoplasmCervical Cancer and HPV ResearchHepatitis B Virus StudiesVirus-based gene therapy research