Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases
Esmee K. van der Ploeg, Korneliusz Golebski, Menno van Nimwegen, Joannah R. Fergusson, Balthasar A. Heesters, Itziar Martínez-González, Chantal M. A. Kradolfer, Sophie van Tol, Brendon P. Scicluna, Marjolein J. W. de Bruijn, Geertje M. de Boer, Gerdien A. Tramper‐Stranders, Gert‐Jan Braunstahl, Wilfred F. J. van IJcken, A. Paul Nagtegaal, Cornelis M. van Drunen, Wytske J. Fokkens, Danny Huylebroeck, Hergen Spits, Rudi W. Hendriks, Ralph Stadhouders, Suzanne M. Bal
Abstract
inflammatory ILC2s as a human analog of mouse iILC2s linked to severe type 2 inflammatory disease and therapy resistance.
Topics & Concepts
Respiratory systemImmunologyPopulationImmunopathologyRespiratory diseaseBiologyInflammationMedicinePathologyLungInternal medicineEnvironmental healthIL-33, ST2, and ILC PathwaysEosinophilic Esophagitis