Development of a highly potent and selective degrader of LRRK2
John M. Hatcher, Monika Zwirek, Adil R. Sarhan, Prasanna S. Vatsan, Francesca Tonelli, Dario R. Alessi, Paul Davies, Nathanael S. Gray
Topics & Concepts
LRRK2NeurodegenerationKinaseChemistryScaffold proteinDrug discoveryCell biologyPharmacologyBiochemistrySignal transductionMutationDiseaseBiologyGeneMedicineInternal medicineProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysSignaling Pathways in Disease