An inulin-type fructan CP-A from <i>Codonopsis pilosula</i> alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics
Jiangtao Zhou, Jiajing Wang, Deyun Li, Zhijia Zhang, Changjian Wang, Xuepeng Zhang, Xiexin Xu, Jianping Gao
Abstract
CP-A exhibits a therapeutic effect on experimental colitis. Its mechanism may be to alleviate intestinal inflammation by preventing the activation of mammalian target of rapamycin (mTOR)/p70S6K signaling pathway. These findings offer a fresh approach to treating ulcerative colitis (UC) and a theoretical foundation for the future advancement of CP-A.
Topics & Concepts
Ulcerative colitisInulinCodonopsisFructanPI3K/AKT/mTOR pathwayMedicineInflammationRehmannia glutinosaTraditional medicineSignal transductionBiologyTraditional Chinese medicineImmunologyInternal medicineDiseaseBiochemistryPathologySucroseAlternative medicineMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented FoodsGut microbiota and health