Wolframin-1–expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice
Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C. Hays, Patrick R. Hof, W. Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer I. Luebke, Tsuneya Ikezu
Abstract
cells in the CA1. Last, a fear conditioning task revealed deficits in trace and contextual memory in mice overexpressing human mutant tau in the ECII. This work demonstrates tau transfer from the ECII to CA1 in mouse brain and provides an early Braak stage preclinical model of AD.
Topics & Concepts
Dentate gyrusEntorhinal cortexNeuroscienceHippocampal formationHippocampusSubiculumBiologyAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors Study