Antifungal activity of designed α-helical antimicrobial peptides
Ruicheng Xu, Jing Tang, Roja Hadianamrei, Suyu Liu, Songwei Lv, Rongrong You, Fang Pan, Peng Zhang, Nan Wang, Zhiqiang Cai, Xiubo Zhao
Abstract
in mice and showed superiority over fluconazole for treating infection and accelerating wound healing. There was an interplay between the hydrophobicity and positive charge density to determine the antifungal activity of the peptides. The results from this study suggest this class of antifungal peptides as promising candidates for antifungal drugs with high efficiency, high biocompatibility and low propensity for drug resistance.
Topics & Concepts
Candida albicansAntimicrobial peptidesPeptideAntimicrobialCorpus albicansAntifungalChemistryBiochemistryAntibioticsDefensinMicrobiologyBiologyAntimicrobial Peptides and ActivitiesProtein Hydrolysis and Bioactive PeptidesAntimicrobial agents and applications