Red-light modulated <i>ortho</i> -chloro azobenzene photoswitch for peptide stapling <i>via</i> aromatic substitution
Mia Kapun, F. Javier Pérez-Areales, Nicola Ashman, Pamela J. E. Rowling, Tim Schober, Elaine Fowler, Laura S. Itzhaki, David R. Spring
Abstract
Development and proof-of-concept for a photoswitchable peptide staple with the ability to trigger a major change in binding affinity upon visible light irradiation.
Topics & Concepts
PhotoswitchAzobenzeneSubstitution (logic)PeptideChemistryStereochemistryPhotochemistryOrganic chemistryBiochemistryMoleculeComputer scienceProgramming languagePhotochromic and Fluorescence ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery