The Biosynthetic Pathway of Ubiquinone Contributes to Pathogenicity of Francisella novicida
Katayoun Kazemzadeh, Mahmoud Hajj Chehade, Gautier Hourdoir, Camille Dorothée Brunet, Yvan Caspar, Laurent Loiseau, Frederic Barras, Fabien Pierrel, Ludovic Pelosi
Abstract
is the major quinone identified in the membranes of Francisella novicida. We identified a new competitive inhibitor that strongly decreased the biosynthesis of UQ. Our demonstration of the crucial roles of UQ for the respiratory metabolism of F. novicida and for the involvement in its pathogenicity in the Galleria mellonella model should stimulate the search for selective inhibitors of bacterial UQ biosynthesis.
Topics & Concepts
FrancisellaBiologyFrancisella tularensisTularemiaMicrobiologyHeterologousVirulenceEscherichia coliPathogenicity islandComplementationInfectivityYersinia pestisGalleria mellonellaCLPBHeterologous expressionBurkholderia cenocepaciaPathogenicityType VI secretion systemPathogenBacteriaBacteriologyPeriplasmic spaceVirologyHuman pathogenBacterial geneticsGeneticsBacillus and Francisella bacterial researchEnzyme Structure and FunctionViral Infections and Outbreaks Research