Synthesis and characterization of Fe3O4@SiO2@MIL-100(Fe) nanocomposite: A nanocarrier for loading and release of celecoxib
Aseman Lajevardi, Moayad Hossaini Sadr, Alireza Badiei, Mahsa Armaghan
Abstract
In this paper, a magnetic and highly porous nanocarrier was synthesized via growing the MIL-100(Fe) on Fe 3 O 4 @SiO 2 nanoparticles. The effect of several factors on celecoxib adsorption and its release behavior were investigated. The adsorption of celecoxib on Fe 3 O 4 @SiO 2 @MIL-100(Fe) NPs followed the Langmuir isotherm model, indicating the monolayer sorption of the drug molecules on the active sites of the nanocarrier . The adsorption process was completed in only 30 min, followed by the pseudo-second-order and intraparticle adsorption kinetic model. The release study at different pH showed that there is a controlled release at physiological pH (~7.4) while the release becomes burst at acidic pH. The result described by the Higuchi and the Korsmeyer-Peppas release kinetic models for neutral pH (i.e., 7.4) and acidic pH, respectively. The cytotoxicity of the as-synthesized nanocarrier was investigated using MTT assay. The developed nanocarrier showed high biocompatibility with normal NIH-3T3 cells. However, the release in the acidic environment of Hela cancer cells revealed the high potential of the developed nanocarrier for future In-vivo studies.