Elastase-targeting biomimic nanoplatform for neurovascular remodeling by inhibiting NETosis mediated AlM2 inflammasome activation in ischemic stroke
Chunming Tang, Feng Jia, Min Wu, Yanling Wang, Xiaowei Lu, Jinyu Li, Yan Ding, Weilin Chen, Xufeng Chen, Feng Han, Huae Xu
Topics & Concepts
NeuroinflammationInflammasomeNeutrophil extracellular trapsProinflammatory cytokineNeutrophil elastaseCell biologyBlood–brain barrierMicrogliaChemistryInflammationElastaseImmunologyNeuroscienceMedicineBiologyBiochemistryCentral nervous systemEnzymeNeutrophil, Myeloperoxidase and Oxidative MechanismsS100 Proteins and AnnexinsIntracranial Aneurysms: Treatment and Complications