Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors
Andrea L. Casillas, Shailender S. Chauhan, Rachel K. Toth, Alva G. Sainz, Amber N. Clements, Corbin C. Jensen, Paul R. Langlais, Cindy K. Miranti, Anne E. Cress, Noel A. Warfel
Topics & Concepts
AngiogenesisPIM1BiologyPhosphorylationCancer researchKinaseCell biologySignal transductionOxygen tensionRegulatorBiochemistrySerineChemistryGeneOxygenOrganic chemistryCancer Mechanisms and TherapyPeptidase Inhibition and AnalysisMechanisms of cancer metastasis