Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens
Suresh Kumar, Ashish Jain, Seong Won Choi, Gustavo Peixoto Duarte da Silva, Lee Allers, Michal Mudd, Ryan Peters, Jan Haug Anonsen, Tor Erik Rusten, Michael Lazarou, Vojo Deretić
Topics & Concepts
TFEBAutophagyCell biologyATG8BiologyMechanistic target of rapamycinPI3K/AKT/mTOR pathwayBasic helix-loop-helix leucine zipper transcription factorsRegulatorActivator (genetics)Transcription factorSignal transductionGeneticsGeneDNA-binding proteinApoptosisAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismPhagocytosis and Immune Regulation