Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer
Se Hyo Jeong, Hun Hwan Kim, Sang Eun Ha, Min Young Park, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Kwang‐Il Park, Jeong‐Doo Heo, Hyun Wook Kim, Gon Sup Kim
Abstract
Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and takes many lives. Apoptosis is a programmed cell death mechanism and if it does not function correctly in cancer cells, it can lead to severe disease. There are various signaling pathways for regulating apoptosis in cancer cells. Flavonoids are non-artificial natural bioactive compounds that are gaining attention as being capable of for inducing apoptosis in cancer cells. Among these, in this study, we focus on flavones. Flavones are a subclass of the numerous available flavonoids and possess several bioactive functions. Some of the most reported and well-known critical flavones, namely apigenin, acacetin, baicalein, luteolin, tangeretin, and wogonin, are discussed in depth in this review. Our main aim is to investigate the effects of the selected flavones on apoptosis and cell signaling pathways that contribute to death due to various types of cancers.