Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition
Mai Q. Nguyen, Jessica L.F. Teh, Timothy J. Purwin, Inna Chervoneva, Michael A. Davies, Katherine L. Nathanson, Phil F. Cheng, Mitchell P. Levesque, Reinhard Dummer, Andrew E. Aplin
Topics & Concepts
TrametinibMAPK/ERK pathwayNeuroblastoma RAS viral oncogene homologMEK inhibitorDownregulation and upregulationKinaseCancer researchMelanomaSignal transductionProtein kinase APhosphorylationCell biologyChemistryBiologyMutationBiochemistryKRASGeneMelanoma and MAPK PathwaysPI3K/AKT/mTOR signaling in cancerHistone Deacetylase Inhibitors Research