Co-immobilization of metal and enzyme into hydrophobic nanopores for highly improved chemoenzymatic asymmetric synthesis
Liya Gao, Zihan Wang, Yunting Liu, Pengbo Liu, Shiqi Gao, Jing Gao, Yanjun Jiang
Abstract
Chemoenzymatic catalysts with hydrophobic nanopores were fabricated by co-immobilizing metal nanoparticles and enzymes into the dendritic organosilica nanoparticles. They demonstrated highly improved catalytic performance in chemoenzymatic asymmetric synthesis of chiral amines and alcohols. The hydrophobic microenvironment proved to be critical to enhanced stability, activity and cascade efficiency.
Topics & Concepts
NanoporeCatalysisChemistryMetalNanoparticleCombinatorial chemistryEnzymeHydrophobic effectEnzyme catalysisChemical engineeringMaterials scienceNanotechnologyOrganic chemistryEngineeringElectrocatalysts for Energy ConversionEnzyme Catalysis and ImmobilizationSurface Chemistry and Catalysis