A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies
Yunhee Kang, Ying Zhou, Yujing Li, Yanfei Han, Jie Xu, Weibo Niu, Ziyi Li, Shiying Liu, Hao Feng, Wen Huang, Ranhui Duan, Tianmin Xu, Nisha Raj, Feiran Zhang, Juan Dou, Chongchong Xu, Hao Wu, Gary J. Bassell, Stephen T. Warren, Emily G. Allen, Peng Jin, Zhexing Wen
Topics & Concepts
ForebrainFragile X syndromeNeurogenesisNeuroscienceBiologyOrganoidMetabotropic glutamate receptorCell biologyGlutamate receptorCentral nervous systemGeneticsReceptorGenetics and Neurodevelopmental DisordersEpigenetics and DNA MethylationCongenital heart defects research