Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis
Hua Zhang, Yongyuan Ma, Xinying Cheng, Dongbo Wu, Xingming Huang, Бин Чэн, Yafeng Ren, Wei Jiang, Xiaoqiang Tang, Ting Bai, Yutian Chen, Yilin Zhao, Chunxue Zhang, Xia Xiao, Jing Liu, Yue Deng, Tinghong Ye, Lu Chen, Lu Chen, Hanmin Liu, Scott L. Friedman, Liping Chen, Liping Chen, Bi‐Sen Ding, Zhongwei Cao
Abstract
17 cells to the liver. Pharmacological targeting of HDAC2 and DNMT1 alleviated fibrosis in a minipig NASH model. We conclude that epigenetically reprogrammed vascular adaptation contributes to liver fibrosis. Targeting of a vascular adaptation node might block maladaptive vascularization to promote liver regeneration in NASH.
Topics & Concepts
CirrhosisSteatohepatitisCancer researchHepatic stellate cellFibrosisBiologyMaladaptationEpigeneticsMedicinePathologyFatty liverImmunologyInternal medicineGeneticsDiseaseGeneLiver Disease Diagnosis and TreatmentLiver Disease and TransplantationLiver physiology and pathology