The effects of allosteric and competitive inhibitors on ZIKV protease conformational dynamics explored through smFRET, nanoDSF, DSF, and 19F NMR
Hannah Maus, Stefan Hammerschmidt, G. Hinze, Fabian Barthels, Victor Hugo Pérez Carrillo, Ute A. Hellmich, Thomas Basché, Tanja Schirmeister
Topics & Concepts
Allosteric regulationNS3ChemistryDengue virusProteaseFörster resonance energy transferZika virusFlavivirusPolyproteinsBiophysicsVirologyDengue feverStereochemistryBiochemistryVirusEnzymeBiologyQuantum mechanicsFluorescencePhysicsMosquito-borne diseases and controlMalaria Research and ControlInsect symbiosis and bacterial influences