Aptamer-functionalized pH-sensitive liposomes for a selective delivery of echinomycin into cancer cells
Zainab Lafi, Walhan Alshaer, Ma’mon M. Hatmal, Malek Zihlif, Dana A. Alqudah, Hamdi Nsairat, Hanan Azzam, Talal Aburjaı, Yasser Bustanji, Abdalla Awidi
Abstract
-ECγCD for the tumor cell lines compared to the normal cell line after 72 h were MDA-MB-231 (43.3), MCF7 (16.9), and A549 (8.5). Furthermore, SI after 3 h for the three cancer cell lines were 4.7, 2.5, 2.8, respectively.
Topics & Concepts
AptamerChemistryLiposomeCombinatorial chemistryCancer cellNanocarriersCancer therapyBiophysicsBiochemistryDrug deliveryCancerMolecular biologyOrganic chemistryBiologyGeneticsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery