Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction
Daniel Daou, Thomas G. Gillette, Joseph A. Hill
Abstract
Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure and a significant public health concern for which limited effective therapies exist. Inflammation triggered by comorbidity burden is a critical element of HFpEF pathophysiology. Here, we discuss evidence for comorbidity-driven systemic and myocardial inflammation and the mechanistic role of inflammation in pathological myocardial remodeling in HFpEF.
Topics & Concepts
Heart failure with preserved ejection fractionHeart failureComorbidityInflammationMedicineEjection fractionCardiologyInternal medicinePathophysiologySystemic inflammationPathologicalCardiovascular Function and Risk FactorsHeart Failure Treatment and ManagementCardiac Fibrosis and Remodeling