CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer
Binhan Wang, Manni Wang, Danyi Ao, Xiawei Wei
Abstract
Chemokine C-X-C motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays an important role in the immune system. The interaction between CXCL13 and its receptor, the G-protein coupled receptor (GPCR) CXCR5, builds a signaling network that regulates not only normal organisms but also the development of many diseases. However, the precise action mechanism remains unclear. In this review, we discussed the functional mechanisms of the CXCL13-CXCR5 axis under normal conditions, with special focus on its association with diseases. For certain refractory diseases, we emphasize the diagnostic and therapeutic role of CXCL13-CXCR5 axis.
Topics & Concepts
CXCL13CXCR5ChemokineG protein-coupled receptorCCL21Chemokine receptorImmune systemCancer researchSignal transductionBiologyCell biologyImmunologyChemokine receptors and signalingImmunotherapy and Immune ResponsesCytokine Signaling Pathways and Interactions