Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
Radim Vrzal
Abstract
Cytochrome P450 2A13 is an omitted brother of CYP2A6 that has an important role in the drug metabolism of liver. Due to extrahepatic expression, it has gained less attention than CYP2A6, despite the fact that it plays a significant role in toxicant-induced pulmonary lesions and, therefore, lung cancer. The purpose of this mini-review is to summarize the basic knowledge about this enzyme in relation to the substrates, inhibitors, genetic polymorphisms, and transcriptional regulation that are known so far (September 2021).
Topics & Concepts
CYP2A6BiologyCytochrome P450EnzymeGeneticsDrug metabolismLung cancerMedicinePathologyBiochemistryCYP1A2Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsDrug-Induced Hepatotoxicity and Protection