Synthesis of fused 1,2,3-triazoles of Clioquinol via sequential CuAAC and C H arylation; in vitro anticancer activity, in silico DNA topoisomerase II inhibitory activity and ADMET
M. Srinivas Reddy, Narasimha Swamy Thirukovela, Sirassu Narsimha, M. Ravinder, Satheesh Kumar Nukala
Topics & Concepts
ChemistryIn silicoClick chemistryHeLaADMECycloadditionTopoisomeraseStereochemistryTriazolePharmacophoreIn vitroCombinatorial chemistryAzideDocking (animal)Lipinski's rule of fivePodophyllotoxinBiochemistryOrganic chemistryGeneMedicineNursingCatalysisClick Chemistry and ApplicationsCancer therapeutics and mechanismsSynthesis and Biological Evaluation