Pyrazolo[3,4-d]pyrimidine derivatives as EGFRT790M and VEGFR-2 dual TK inhibitors: Design, synthesis, molecular docking, ADMET profile and anticancer evaluations
Dina Adel, Khaled El‐Adl, Tamer Nasr, Tamer M. Sakr, Wafaa A. Zaghary
Topics & Concepts
ChemistryErlotinibSorafenibPyrimidineDocking (animal)PharmacologyA549 cellIn silicoEGFR inhibitorsDrugStereochemistryIn vitroCancer researchBiochemistryReceptorEpidermal growth factor receptorGeneBiologyHepatocellular carcinomaMedicineNursingSynthesis and biological activityCancer Mechanisms and TherapyLung Cancer Treatments and Mutations