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Central Nervous System–Specific Outcomes of Phase 3 Randomized Clinical Trials in Patients With Advanced Breast Cancer, Lung Cancer, and Melanoma

Kathryn Corbett, Alisha Sharma, Gregory R. Pond, Priscilla K. Brastianos, Sunit Das, Arjun Sahgal, Katarzyna J. Jerzak

2021JAMA Oncology27 citationsDOIOpen Access PDF

Abstract

This cohort study determines the proportion of phase 3 clinical trials for patients with metastatic breast cancer, lung cancer, and melanoma that included patients with brain metastases and/or evaluated central nervous system–specific end points.

Topics & Concepts

MedicineBreast cancerLung cancerMelanomaOncologyCancerInternal medicineClinical trialCentral nervous systemMetastatic breast cancerRandomized controlled trialCancer researchBrain Metastases and TreatmentGlioma Diagnosis and TreatmentCancer, Stress, Anesthesia, and Immune Response
Central Nervous System–Specific Outcomes of Phase 3 Randomized Clinical Trials in Patients With Advanced Breast Cancer, Lung Cancer, and Melanoma | Litcius