A near-infrared and lysosome-targeted BODIPY photosensitizer for photodynamic and photothermal synergistic therapy
Yan Liu, Jie Gao, Hongyu Li, Mingyan Yang, Jiajia Lv, Yaping Zhou, Zeli Yuan, Xinmin Li
Abstract
A multifunctional BODIPY derivative Lyso-BDP was prepared. It shows near-infrared absorption and emission, photosensitizing activity, lysosomal targeting, and synergistic PDT and PTT effects, and kills cancer cells both in vitro and in vivo .
Topics & Concepts
ChemistryPhotodynamic therapyPhotosensitizerPhotothermal therapyBODIPYLysosomeCancer researchBiophysicsPhotochemistryNanotechnologyBiochemistryFluorescenceEnzymeOrganic chemistryMedicineOpticsBiologyPhysicsMaterials scienceNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials