<i>Lacticaseibacillus rhamnosus</i> HF01 fermented yogurt alleviated high-fat diet-induced obesity and hepatic steatosis <i>via</i> the gut microbiota–butyric acid–hepatic lipid metabolism axis
Yue Sun, Xiaolin Liu, Rongchun Wang, Rongmei Liu, Xuepeng Lv, Ying Ma, Qiming Li
Abstract
. These alterations led to an increase of the cecum butyric acid content, which in turn indirectly promoted the activation of the AMPK signaling pathway, subsequently, inhibited fat synthesis, and promoted fatty acid oxidation related gene expression. Therefore, HF01-Y was likely to alleviate hepatic fat and relieve obesity by modulating the gut microbiota-butyric acid-hepatic lipid metabolism axis, ultimately promoting host health.
Topics & Concepts
Gut floraSteatosisButyric acidLipid metabolismCecumBiologyEndocrinologyInternal medicineBiochemistryMedicineGut microbiota and healthDiet and metabolism studiesTryptophan and brain disorders