PCC0208023, a potent SHP2 allosteric inhibitor, imparts an antitumor effect against KRAS mutant colorectal cancer
Xiao Chen, Fangxia Zou, Zhengping Hu, Guangying Du, Pengfei Yu, Wenyan Wang, Hongbo Wang, Liang Ye, Jingwei Tian
Topics & Concepts
Allosteric regulationKRASColorectal cancerCancer researchChemistryMAPK/ERK pathwayIn vivoReceptor tyrosine kinaseIn vitroMutantKinaseCancerPharmacologyEnzymeBiologyMedicineBiochemistryInternal medicineBiotechnologyGeneProtein Tyrosine PhosphatasesBioactive Compounds and Antitumor AgentsGalectins and Cancer Biology