Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis
Xi Zhang, Daqi Yu, Jingchuan Sun, Yujie Wu, Junyuan Gong, Xuemei Li, Li Liu, Shan Liu, Jianbo Liu, Yulan Wu, Dongyang Li, Yinping Ma, Han Xu, Yanan Zhu, Zhaolong Wu, Yihua Wang, Qi Ouyang, Tao Wang
Topics & Concepts
EctodomainInsulin receptorReceptor tyrosine kinaseReceptorInsulin receptor substrateCell biologyIRS2BiophysicsTyrosine kinaseInsulin-like growth factorChemistryBiologySignal transductionBiochemistryInsulinGrowth factorEndocrinologyInsulin resistanceGrowth Hormone and Insulin-like Growth FactorsGlycosylation and Glycoproteins ResearchEnzyme Structure and Function