Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke
Irene Sánchez‐Morán, Cristina Rodríguez, Rebeca Lapresa, Jesús Agulla, Tomás Sobrino, José Castillo, Juan P. Bolaños, Ángeles Almeida
Abstract
human nonsynonymous single-nucleotide polymorphism (SNP) rs2287499 (c.202C>G). Patients carrying this SNP showed less infarct volume and better functional outcome after stroke. These results indicate that WRAP53 fosters DNA repair and neuronal survival to promote functional recovery after stroke.
Topics & Concepts
Stroke (engine)Stroke recoveryNeuroscienceBiologyMedicinePhysicsRehabilitationThermodynamicsUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysMicrotubule and mitosis dynamics