Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli
Zhihao Chen, Fan Zhao, Chao Liang, Lifang Hu, Dijie Li, Yan Zhang, Chong Yin, Lei Chen, Luyao Wang, Xiao Lin, Peihong Su, Jianhua Ma, Chaofei Yang, Ye Tian, Wenjuan Zhang, Yu Li, Songlin Peng, Weiyi Chen, Ge Zhang, Airong Qian
Abstract
These data suggest that miR-138-5p as a mechanoresponsive miRNA accounts for the mechanosensitivity of the bone anabolic response and that inhibition of miR-138-5p in osteoblasts may be a novel bone anabolic sensitization strategy for ameliorating disuse or senile osteoporosis.
Topics & Concepts
AnabolismOsteoblastOsteoporosisGene silencingAnabolic AgentsInternal medicineBone healingChemistryMedicineEndocrinologyCell biologyBiologyAnatomyIn vitroBiochemistryGeneMicroRNA in disease regulationBone Metabolism and DiseasesRNA Research and Splicing