Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA5-Dependent Signaling
Zhongxing Liang, Peijian He, Yiran Han, C. Chris Yun
Abstract
BACKGROUND & AIMS: receptor as a potent regulator of the survival of stem cells and transit-amplifying cells in the intestine. METHODS: ) mice. Mice were treated with tamoxifen or β-naphthoflavone to delete Lpar5 expression. Enteroids derived from these mice were used to determine the effect of Lpar5 loss on the apoptosis and proliferation of crypt epithelial cells. RESULTS: -dependent suppression of CXCL10. CONCLUSIONS: regulates survival of stem cells and transit-amplifying cells in the intestine.
Topics & Concepts
Progenitor cellStem cellCell biologyProgenitorBiologyCancer researchCancer Cells and MetastasisPI3K/AKT/mTOR signaling in cancerCaveolin-1 and cellular processes