New trends in antifungal treatment: What is coming up?
Jesús Guinea
Abstract
New antifungal agents are needed to overcome limitations of available ones such as poor pharmacokinetic traits, toxicity, drug-drug interactions, limited clinical efficacy, and emerging antifungal resistance. New antifungal drugs belong to well-known families (azoles, polyenes, or beta-d-glucan synthase inhibitors) or to drug families showing completely new mechanisms of action. Some drugs have a head start in terms of potential to reach the clinical setting and are here reviewed.
Topics & Concepts
AntifungalAntifungal drugAntifungal drugsDrugPharmacologyMedicineDrug resistancePharmacokineticsBiologyMicrobiologyDermatologyAntifungal resistance and susceptibilityNail Diseases and TreatmentsSynthesis and biological activity