The Tol Pal system integrates maintenance of the three layered cell envelope
Joanna Szczepaniak, Melissa N. Webby
Abstract
The rapid emergence of antibiotic-resistant superbugs poses a significant global health threat. Gram-negative bacteria are the primary culprits due to their robust, tripartite cell envelope. This review explores the emerging role of the trans-envelope Tol-Pal system in maintaining envelope integrity, by connecting envelope layers and serving as a protein interaction hub. Targeting the Tol-Pal system offers a promising approach for the development of novel envelope-disrupting antimicrobials.
Topics & Concepts
Envelope (radar)Cell envelopeBuilding envelopeBiologyComputer scienceComputational biologyEngineeringPhysicsGeneticsTelecommunicationsRadarEscherichia coliThermalGeneMeteorologyBacterial Genetics and BiotechnologyBacteriophages and microbial interactionsAntibiotic Resistance in Bacteria