SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases
Hannah Maus, Fabian Barthels, Stefan Hammerschmidt, Katja Kopp, Benedikt Millies, Andrea Gellert, Alessia Ruggieri, Tanja Schirmeister
Topics & Concepts
NS3Allosteric regulationDengue virusChemistryFlavivirusCapsidVirologyProteaseProteasesZika virusDengue feverVirusBiologyBiochemistryEnzymeMosquito-borne diseases and controlViral Infections and VectorsInsect symbiosis and bacterial influences