Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in Pennsylvania
Andrew D. Marques, Scott Sherrill-Mix, J.K. Everett, Hriju Adhikari, Shantan Reddy, Julie C. Ellis, Haley Zeliff, Sabrina S. Greening, Carolyn C. Cannuscio, Katherine M. Strelau, Ronald G. Collman, Brendan J. Kelly, Kyle G. Rodino, Frederic D. Bushman, Roderick B. Gagne, Eman Anis
Abstract
Coronaviruses have been documented to replicate in numerous species of vertebrates, and multiple spillovers of coronaviruses from animals into humans have founded human epidemics. The COVID-19 epidemic likely derived from a spillover of SARS-CoV-2 from bats into humans, possibly via an intermediate host. There are now several examples of SARS-CoV-2 jumping from humans into other mammals, including mink and deer, creating the potential for new animal reservoirs from which spillback into humans could occur. For this reason, data on formation of new animal reservoirs is of great importance for understanding possible sources of future infection. Here, we identify extensive infection in white-tailed deer in Pennsylvania, including what appear to be multiple independent transmissions. Data further suggests possible transmission among deer. These data thus help identify a potential new animal reservoir and provide background information relevant to its management.