Precise Rate Control of Pseudorotaxane Dethreading by pH-Responsive Selectively Functionalized Cyclodextrins
Sawsen Cherraben, Jérémy Scelle, Bernold Hasenknopf, Guillaume Vives, Matthieu Sollogoub
Abstract
A family of cyclodextrins functionalized with zero, one, two, or six amines was shown to control the rate of their threading and dethreading on a molecular axle depending on the pH and their substitution pattern. The originality of this system lies in the rate control of the switch by operating the stimulus directly on the macrocycle.
Topics & Concepts
ChemistryThreading (protein sequence)CyclodextrinCombinatorial chemistryStereochemistryOrganic chemistryBiochemistryProtein structureSupramolecular Chemistry and ComplexesChemical Synthesis and AnalysisMolecular Sensors and Ion Detection