C–H bond activation <i>via</i> concerted metalation–deprotonation at a palladium( <scp>iii</scp> ) center
Bailey S. Bouley, Fengzhi Tang, Dae Young Bae, Liviu M. Mirica
Abstract
ligand coordination and that the flexible ligand structure is important for this transformation. Overall, this study represents the first example of discrete C-H bond activation occurring at a Pd(iii) center through a concerted metalation-deprotonation mechanism, akin to that observed for Pd(ii) and Pd(iv) centers.
Topics & Concepts
MetalationDeprotonationPalladiumChemistryStereochemistryCenter (category theory)Medicinal chemistryCatalysisOrganic chemistryCrystallographyIonCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms