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Discovery of degrader for FLT3, GSPT1 and IKZF1/3 proteins merging PROTAC and molecular glue targeting FLT3-ITD mutant acute myeloid leukemia

Yang Yu, Qian Yao, Dan Song, Ke-Xin Tang, Zijun Tang, Mingxing Hu, Yi Luo, Yongmei Xie

2025European Journal of Medicinal Chemistry11 citationsDOI

Topics & Concepts

ChemistryMyeloid leukemiaMutantCancer researchBiochemistryGeneBiologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors Research
Discovery of degrader for FLT3, GSPT1 and IKZF1/3 proteins merging PROTAC and molecular glue targeting FLT3-ITD mutant acute myeloid leukemia | Litcius